Saturday, 3 March 2018

How to rectify neurodevelopmental disorder in human?


                   How to rectify neurodevelopmental disorder?

                                                                                    Date 29-1-2018
Nalin Ranjan, Scientist

BBC News

How to suppress depression and other forms of mental diseases?

    I am surprise to see an article titled as “IIT Kanpur team finds possible cause of neurodevelopmental disorders” appeared in a popular News paper called ‘The Hindu’ dated 28-1-2018 stating Bone morphagenetic protein (BMP) are secreted signaling molecules which are already known to regulate the production of neurons from neural stem cells. Now using mice models, a team of researchers led by Prof. Jonaki Sen From the Indian Institute of Technology (IIT) Kanpur has found that BMP signalling is active in the cerebral cortex during embryonic development as well as during later stages of development after birth, too.
I would like to put in a more perspective way that early formation of neurons from bone morphogenetic protein through its signaling process newborn neurons migrates and niche at their right places that comes with polarity (the axon forming the base and dendrites forming on apical side on top of neuronal cells only when branching of dendrites some perturbation occurs giving wrong connection between neurons that leads to mental disorder. But 90% of people are mentally healthy by the early-born neurons that form inner cortical layers while late born neurons even after birth forms correctly. This is achieved by Bone Morphogenetic protein signaling the molecules are the ones that regulate the production of newborn neurons from very neural stem cells during embryonic stage as well as after birth too.

     So early stage of forming cerebral cortex by newborn neurons already migrated and destined at the right place and polarity (the axons forming the base and dendrites too are falling in place with them makes the cerebral cortex healthy.  Sometimes perturbation occurs in dendrites branching on the apical side without proper connection between neurons can cause diseases  in some people such as lisencephlay, autism, epilepsy and schizophrenia,” as stated by Prof. Sen who is with the Department of Biological Sciences and Bioengineering at Indian Institute of Technology, Kanpur-INDIA.
    Now, such types of diseases can be avoided once you make young children from age of four if they start climbing trees either coconut tree or any metal post four times a day for a period of 15 years. With their four limb action lifting the whole body weight, dendrites would automatically realign itself in giving connection between active neurons during brain developing stage. By regular climbing, one can easily avoid mental disorder by this four limb action. This I had already analysed and published in one of my papers calledWhy male elephant gets affected by musth and why not in female elephant”. Now this can be assessed from the following website.

Also read an interesting paper titled as “How to avoid sleepwalking & sleepless nights in children’ published in my web site as follow

Let this beauty speaks through four limb action.
     Nalin Ranjan
Brain Research Work

Copy of this report posted to Dr. Michio Kaku, Scientist from United States –California” on 29-1-2018
Copy of this report posted to “Imperial College Neuroscience Society” on 29-1-2018
Copy of this report posted to “Jennifer Klay, Asst Professor of Physics at California Polytechnic State University, San Luis Obispo” on 29-1-2018
Copy of this report posted to Dr. Stephen Hawking, Scientist from London” on 29-1-2018
Copy of this report posted to “Neil Degrasse Tyson From United States –New York” on 29-1-2018
Copy of this report posted to Dr. Lawrence Krauss, Scientist from United States –California” on 30-1-2018
Copy of this report posted to “Dr Philip Plait, Scientist from United States –California” on 30-1-2018
Copy of this report posted to “St Mary’s University- Twickenham” on 30-1-2018
Copy of this report posted to “The Hindu as well as Times Now” on 1-2-2018
Copy of this report posted to “Donald Trump, The President of United States” on 29-1-2018

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